Nicholas W Morrell Selected Research

Bone Morphogenetic Proteins (Bone Morphogenetic Protein)

1/2022	Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10.
1/2022	Single-cell RNA sequencing reveals that BMPR2 mutation regulates right ventricular function via ID genes.
7/2020	Targeting translational read-through of premature termination mutations in BMPR2 with PTC124 for pulmonary arterial hypertension.
1/2020	4PBA Restores Signaling of a Cysteine-substituted Mutant BMPR2 Receptor Found in Patients with Pulmonary Arterial Hypertension.
1/2018	Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.
1/2018	A novel piperidine identified by stem cell-based screening attenuates pulmonary arterial hypertension by regulating BMP2 and PTGS2 levels.
11/2017	Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension.
10/2017	Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling.
1/2017	TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.
1/2016	MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension.

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Nicholas W Morrell Research Topics

Disease

80	Pulmonary Arterial Hypertension 04/2022 - 08/2004
34	Pulmonary Hypertension 01/2021 - 04/2002
27	Familial Primary Pulmonary Hypertension 12/2021 - 04/2002
26	Vascular Remodeling 01/2019 - 11/2004
23	Hypoxia (Hypoxemia) 01/2021 - 12/2002
12	Inflammation (Inflammations) 01/2019 - 06/2009
8	Right Ventricular Hypertrophy 03/2017 - 03/2006
5	Neoplasms (Cancer) 01/2020 - 11/2010
4	Hereditary Hemorrhagic Telangiectasia 12/2021 - 06/2009
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 12/2014
4	Vascular Diseases (Vascular Disease) 04/2015 - 06/2009
4	Infections 08/2011 - 03/2004
3	Congenital Heart Defects (Congenital Heart Defect) 01/2022 - 10/2009
3	Telangiectasis (Telangiectasia) 12/2021 - 06/2009
3	Hypertrophy 02/2021 - 05/2008
3	Liver Diseases (Liver Disease) 01/2021 - 01/2019
3	Liver Cirrhosis (Hepatic Cirrhosis) 01/2021 - 08/2011
3	Fibrosis (Cirrhosis) 01/2021 - 01/2017
3	Pneumonia (Pneumonitis) 01/2017 - 12/2013
3	Atherosclerosis 02/2016 - 12/2014
3	Heart Failure 11/2014 - 04/2011
3	Schistosomiasis (Bilharziasis) 08/2011 - 02/2010
2	Rare Diseases (Rare Disease) 10/2021 - 11/2017
2	Disease Progression 10/2021 - 01/2017
2	Right Ventricular Dysfunction 10/2021 - 02/2014
2	Lung Injury 01/2021 - 11/2007
2	Anemia 01/2021 - 01/2013
2	Iron Deficiencies 01/2021 - 01/2013
1	Arteriovenous Malformations (Arteriovenous Malformation) 12/2021
1	Connective Tissue Diseases (Connective Tissue Disease) 10/2021
1	Body Weight (Weight, Body) 01/2021
1	Edema (Dropsy) 01/2021
1	Disease Susceptibility (Diathesis) 01/2020

Drug/Important Bio-Agent (IBA)

47	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 01/2022 - 04/2002
30	Type II Bone Morphogenetic Protein Receptors (Bone Morphogenetic Protein Receptor Type II)IBA 01/2022 - 03/2006
14	MonocrotalineIBA 01/2021 - 02/2009
11	LigandsIBA 04/2022 - 02/2005
11	Proteins (Proteins, Gene)FDA Link 07/2020 - 11/2004
11	Transforming Growth Factors (Transforming Growth Factor)IBA 10/2015 - 11/2004
9	CytokinesIBA 01/2022 - 06/2009
9	MicroRNAs (MicroRNA)IBA 07/2021 - 04/2010
8	Transforming Growth Factor beta (TGF-beta)IBA 09/2013 - 04/2002
7	Semaxinib (SU5416)IBA 01/2021 - 11/2011
6	Biomarkers (Surrogate Marker)IBA 01/2022 - 08/2010
6	hydralazine 4-anisaldehyde hydrazoneIBA 01/2017 - 03/2012
5	Bone Morphogenetic Protein ReceptorsIBA 01/2022 - 01/2010
5	Growth Differentiation Factor 2IBA 01/2021 - 01/2017
5	Phosphotransferases (Kinase)IBA 01/2019 - 02/2009
5	Epoprostenol (Prostacyclin)FDA LinkGeneric 06/2013 - 08/2004
4	pro-brain natriuretic peptide (1-76)IBA 01/2022 - 04/2011
4	EndoglinIBA 06/2020 - 06/2009
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2014 - 06/2009
3	Activins (Activin)IBA 04/2022 - 02/2009
3	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2022 - 04/2013
3	IronIBA 01/2021 - 04/2011
3	ApelinIBA 01/2021 - 03/2017
3	Peptides (Polypeptides)IBA 01/2021 - 03/2017
3	Activin Receptors (Activin Receptor)IBA 01/2020 - 02/2009
3	Messenger RNA (mRNA)IBA 04/2019 - 11/2004
3	erucylphosphocholineIBA 01/2016 - 02/2012
3	Imatinib Mesylate (Gleevec)FDA Link 11/2015 - 11/2010
3	Sildenafil Citrate (Viagra)FDA Link 01/2013 - 08/2008
2	Pharmaceutical PreparationsIBA 01/2022 - 08/2011
2	ProteomeIBA 01/2022 - 01/2022
2	Interleukin-6 (Interleukin 6)IBA 01/2022 - 11/2011
2	Biological ProductsIBA 12/2021 - 10/2021
2	Nonsense Codon (Nonsense Mutation)IBA 12/2021 - 07/2020
2	ferric carboxymaltoseIBA 01/2021 - 01/2013
2	RNA (Ribonucleic Acid)IBA 10/2020 - 01/2020
2	atalurenIBA 07/2020 - 09/2013
2	Carbon MonoxideIBA 01/2020 - 11/2017
2	OsteoprotegerinIBA 11/2019 - 01/2012
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2019 - 01/2018
2	AntigensIBA 01/2019 - 06/2010
2	Transcription Factors (Transcription Factor)IBA 12/2018 - 01/2016
2	Translationally-Controlled 1 Tumor ProteinIBA 10/2018 - 05/2014
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2018 - 11/2004
2	Polypyrimidine Tract-Binding ProteinIBA 12/2017 - 12/2017
2	Pyruvate KinaseIBA 12/2017 - 12/2017
2	DNA (Deoxyribonucleic Acid)IBA 11/2017 - 02/2005
2	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 07/2015 - 11/2011
2	Serotonin (5 Hydroxytryptamine)IBA 06/2015 - 03/2006
2	Endothelin-1 (Endothelin 1)IBA 11/2014 - 02/2014
2	InterferonsIBA 02/2014 - 08/2012
2	Iloprost (Ventavis)FDA Link 02/2011 - 01/2005
2	Transforming Growth Factor beta Receptors (TGF beta Receptors)IBA 06/2009 - 02/2005
2	Protein Isoforms (Isoforms)IBA 01/2005 - 12/2003
2	ProstaglandinsIBA 11/2004 - 12/2002
1	7-(N-(3-aminopropyl)amino)heptan-2-oneIBA 10/2021
1	Leukocyte Elastase (Neutrophil Elastase)IBA 10/2021
1	ElafinIBA 10/2021
1	Toll-Like Receptors (Toll-Like Receptor)IBA 02/2021
1	Dextrans (Dextran)FDA Link 01/2021
1	Transferrin (beta 2 Transferrin)IBA 01/2021
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2021
1	Immunoglobulin G (IgG)IBA 01/2021
1	Ferritins (Ferritin)IBA 01/2021
1	Cysteine (L-Cysteine)FDA Link 01/2020

Therapy/Procedure

18	Therapeutics 04/2022 - 03/2004
3	Endarterectomy (Thromboendarterectomy) 01/2021 - 07/2007